Accurate differentiation between physiological and pathological ripples recorded with scalp-EEG.
Clin Neurophysiol
; 143: 172-181, 2022 11.
Article
en En
| MEDLINE
| ID: mdl-36115810
ABSTRACT
OBJECTIVE:
To compare scalp-EEG recorded physiological ripples co-occurring with vertex waves to pathological ripples co-occurring with interictal epileptiform discharges (IEDs).METHODS:
We marked ripples in sleep EEGs of children. We compared the start of ripples to vertex wave- or IED-start, and duration, frequency, and root mean square (RMS) amplitude of physiological and pathological ripples using multilevel modeling. Ripples were classified as physiological or pathological using linear discriminant analysis.RESULTS:
We included 40 children with and without epilepsy. Ripples started (χ2(1) = 38.59, p < 0.001) later if they co-occurred with vertex waves (108.2 ms after vertex wave-start) than if they co-occurred with IEDs (4.3 ms after IED-start). Physiological ripples had longer durations (75.7 ms vs 53.0 ms), lower frequencies (98.3 Hz vs 130.6 Hz), and lower RMS amplitudes (0.9 µV vs 1.8 µV, all p < 0.001) than pathological ripples. Ripples could be classified as physiological or pathological with 98 % accuracy. Ripples recorded in children with idiopathic or symptomatic epilepsy seemed to form two subgroups of pathological ripples.CONCLUSIONS:
Ripples co-occurring with vertex waves or IEDs have different characteristics and can be differentiated as physiological or pathological with high accuracy.SIGNIFICANCE:
This is the first study that compares physiological and pathological ripples recorded with scalp EEG.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cuero Cabelludo
/
Epilepsia
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Clin Neurophysiol
Asunto de la revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Países Bajos