The association of high-fluoride and high-iodine combined exposure with dental fluorosis and goiter: a meta-analysis.
Environ Geochem Health
; 45(6): 3143-3153, 2023 Jun.
Article
en En
| MEDLINE
| ID: mdl-36155875
ABSTRACT
It is controversial that high-fluoride and high-iodine combined exposure affects the prevalence of dental fluorosis and goiter. The aim of this study was to explore the potential association between high-fluoride and high-iodine combined exposure with dental fluorosis and goiter. We retrieved relevant articles from PubMed, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database and China Science and Technology Journal Database (VIP). The query format was 1 # "Fluorosis" OR "Fluoride," 2 # "Iodine" OR "Iodide," and 3 # 1 AND 2. A total of 20 papers were included in this study after independent review by two investigators. Our analysis showed that high-fluoride and high-iodine biphasic exposure was significantly associated with the prevalence of goiter (OR = 4.69, 95% CI 2.82-7.80, P < 0.001). The prevalence of dental fluorosis was also significantly raised (OR = 11.71, 95% CI 7.57-18.14, P < 0.001). Sensitivity analysis suggested that combined statistics of multiple studies were reliable. For goiter, subgroup analysis revealed study province, sample size and published year as sources of heterogeneity (P < 0.001). For dental fluorosis, only sample size was the impact factor of heterogeneity. As well, funnel plot, Begg's test and Egger's test suggested there was no publication bias (P > 0.05). Overall, our study demonstrates that high-fluoride and high-iodine combined exposure is a risk factor for occurrence of dental fluorosis and goiter. The chronic of high-fluoride and high-iodine combined exposure is a significant higher risk of disease than normal.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Bocio
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Yodo
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Fluorosis Dental
Tipo de estudio:
Risk_factors_studies
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Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Environ Geochem Health
Asunto de la revista:
QUIMICA
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SAUDE AMBIENTAL
Año:
2023
Tipo del documento:
Article
País de afiliación:
China