A single tertiary institution review of the international system for serous fluid cytopathology and the impact of cell block and ancillary studies on its performance.
J Am Soc Cytopathol
; 12(1): 48-57, 2023.
Article
en En
| MEDLINE
| ID: mdl-36192336
ABSTRACT
INTRODUCTION:
We sought to assess the utility of the International System for Serous Fluid Cytopathology (TIS) in the context of our department's routine practice. MATERIALS ANDMETHODS:
We examined 1028 archived effusion cytology (pleural, peritoneal, and pericardial) cases from 2018 to 2019, and re-classified them along the international system into the following diagnostic categories nondiagnostic (ND), negative for malignancy (NFM), atypia cells of undetermined significance (AUS), suspicious for malignancy (SFM), and malignant (MAL).RESULTS:
The full distribution of the cases examined was as follows ND 2.0%; NFM 66.1%; AUS 6.0%; SFM 4.7%; MAL 21.2%. Overall risk of malignancy for each category was calculated as ND 30.0%; NFM 18.0%; AUS 61.9%; SFM 100%; MAL 94.4%. The overall performance attributes of TIS were as follows sensitivity 57.1%; specificity 98.3%; positive predictive value 94.4%; negative predictive value 82.0%; diagnostic accuracy 84.5%.CONCLUSIONS:
The new classification was simple and intuitive to use and our results appear to fall within the expected ranges of the new guidelines, with risk of malignancy and accuracy comparable to similar studies. The availability of a cell block allowed for refinement of the diagnosis in a majority of cases with equivocal cytology, though this was dependent on the cell yield.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Líquidos Corporales
/
Neoplasias
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Am Soc Cytopathol
Año:
2023
Tipo del documento:
Article