Age- and disease-specific reference values for neurofilament light presented in an online interactive support interface.
Ann Clin Transl Neurol
; 9(11): 1832-1837, 2022 11.
Article
en En
| MEDLINE
| ID: mdl-36196979
ABSTRACT
Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age-specific and disease-specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of 1698 individuals without a neurological disorder, aged 19-85 years, and patients with MS and dementias. Percentile regression estimates per diagnosis populate interactive graphs, alongside NfL background information (available on https//mybiomarkers.shinyapps.io/Neurofilament). This accessible interface provides reference for interpretation of the individual patient results for clinicians. It showcases an adaptable method to support interpretation of age-dependent biomarkers in neurology.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Axones
/
Filamentos Intermedios
Límite:
Humans
Idioma:
En
Revista:
Ann Clin Transl Neurol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Países Bajos