The latest breakthrough on NLRP6 inflammasome.
Precis Clin Med
; 5(3): pbac022, 2022 Sep.
Article
en En
| MEDLINE
| ID: mdl-36211635
ABSTRACT
NLRP6, a Nod-like receptor family member, has been shown to affect intestinal homeostasis and microbial colonization through organizing a huge protein complex called inflammasome. NLRP6 inflammasome promotes the cleavage and secretion of inflammatory cytokines or the cleavage of pore-forming Gasdermin D to initiate the inflammatory cell death called pyroptosis, which plays important roles in responding to pathogen invasion. However, questions about the ligand(s) that trigger NLRP6 inflammasome activation, or the mechanisms that how a ligand triggers NLRP6 inflammasome assembly, are emerging. In this mini-review, we summarize the current understandings of ligand recognition of NLRP6, the role of liquid-liquid phase separation in NLRP6 inflammasome assembly, and potential links with human health and diseases.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
Precis Clin Med
Año:
2022
Tipo del documento:
Article
País de afiliación:
China