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Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models.
Gardner, Iain; Xu, Mandy; Han, Chunyan; Wang, Yi; Jiao, Xingjin; Jamei, Masoud; Khalidi, Hiba; Kilford, Peter; Neuhoff, Sibylle; Southall, Roz; Turner, David B; Musther, Helen; Jones, Barry; Taylor, Simon.
Afiliación
  • Gardner I; Certara UK Ltd., Sheffield, United Kingdom.
  • Xu M; Pharmaron Beijing Co. Ltd., Beijing, China.
  • Han C; Pharmaron Beijing Co. Ltd., Beijing, China.
  • Wang Y; Pharmaron Beijing Co. Ltd., Beijing, China.
  • Jiao X; Pharmaron Beijing Co. Ltd., Beijing, China.
  • Jamei M; Certara UK Ltd., Sheffield, United Kingdom.
  • Khalidi H; Certara UK Ltd., Sheffield, United Kingdom.
  • Kilford P; Certara UK Ltd., Sheffield, United Kingdom.
  • Neuhoff S; Labcorp Drug Development, Harrogate, United Kingdom.
  • Southall R; Certara UK Ltd., Sheffield, United Kingdom.
  • Turner DB; Certara UK Ltd., Sheffield, United Kingdom.
  • Musther H; Certara UK Ltd., Sheffield, United Kingdom.
  • Jones B; Certara UK Ltd., Sheffield, United Kingdom.
  • Taylor S; Pharmaron UK, Hoddesdon, Hertfordshire, United Kingdom.
Xenobiotica ; 52(8): 943-956, 2022 Aug.
Article en En | MEDLINE | ID: mdl-36222269
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Microsomas Hepáticos / Hepatocitos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Xenobiotica Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Microsomas Hepáticos / Hepatocitos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Xenobiotica Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido