The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.
Obesity (Silver Spring)
; 31 Suppl 1: 85-95, 2023 02.
Article
en En
| MEDLINE
| ID: mdl-36239695
ABSTRACT
OBJECTIVE:
This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health.METHODS:
Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response.RESULTS:
In the total population (n = 42, 76% women, median age 47 years [IQR 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker ß-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes.CONCLUSIONS:
TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Huesos
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Densidad Ósea
Tipo de estudio:
Clinical_trials
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Obesity (Silver Spring)
Asunto de la revista:
CIENCIAS DA NUTRICAO
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FISIOLOGIA
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METABOLISMO
Año:
2023
Tipo del documento:
Article
País de afiliación:
Suiza