Notch Signaling Mediates Radiation-Induced Smooth Muscle Cell Hypermuscularization and Cerebral Vasculopathy.

Yang, Yuhua; Li, Honghong; Xu, Yongteng; Xie, Jiatian; Liu, Qiang; Shi, Zhongshan; Huang, Jialin; Cheng, Jinping; Chen, Siqi; Chen, Sitai; Zhao, Xiaohui; Li, Shaojian; Zhang, Zhan; Cai, Jinhua; He, Baixuan; Lin, Wei-Jye; Shen, Qingyu; Li, Yi; Tang, Yamei

Yang, Yuhua; Li, Honghong; Xu, Yongteng; Xie, Jiatian; Liu, Qiang; Shi, Zhongshan; Huang, Jialin; Cheng, Jinping; Chen, Siqi; Chen, Sitai; Zhao, Xiaohui; Li, Shaojian; Zhang, Zhan; Cai, Jinhua; He, Baixuan; Lin, Wei-Jye; Shen, Qingyu; Li, Yi; Tang, Yamei.

Afiliación

Yang Y; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Li H; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Xu Y; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Xie J; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Liu Q; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Shi Z; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Huang J; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Cheng J; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Chen S; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Chen S; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Zhao X; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Li S; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Zhang Z; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Cai J; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
He B; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Lin WJ; Brain Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China (W.- J.L., Q.S., Y.L., Y.T.).
Shen Q; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China and Guangdong Province Key Laboratory of Brain Function and
Li Y; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yatsen University, Guangzhou, China (Y.Y., H.L., Y.X., J.X., Q.L., Z.S., J.H., J.C., Siqi Chen, Sitai Chen, X.Z., S.L., Z.Z., J.C., B.H., Q.S., Y.L., Y.T.).
Tang Y; Brain Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China (W.- J.L., Q.S., Y.L., Y.T.).

Stroke ; 53(12): 3751-3762, 2022 12.

Article en En | MEDLINE | ID: mdl-36305312

Asunto(s)

Lesiones Encefálicas; Trastornos Cerebrovasculares; Traumatismos por Radiación; Animales; Ratones; Nimodipina; Miocitos del Músculo Liso/patología; Transducción de Señal; Trastornos Cerebrovasculares/complicaciones; Lesiones Encefálicas/patología; Ésteres/metabolismo; Ésteres/farmacología; Receptores Notch/metabolismo

Palabras clave

cerebrovascular disorders; cognitive dysfunction; radiation injuries; receptors, Notch; smooth muscle cells

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Traumatismos por Radiación / Lesiones Encefálicas / Trastornos Cerebrovasculares Límite: Animals Idioma: En Revista: Stroke Año: 2022 Tipo del documento: Article

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