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A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.
Pita-Juarez, Yered; Karagkouni, Dimitra; Kalavros, Nikolaos; Melms, Johannes C; Niezen, Sebastian; Delorey, Toni M; Essene, Adam L; Brook, Olga R; Pant, Deepti; Skelton-Badlani, Disha; Naderi, Pourya; Huang, Pinzhu; Pan, Liuliu; Hether, Tyler; Andrews, Tallulah S; Ziegler, Carly G K; Reeves, Jason; Myloserdnyy, Andriy; Chen, Rachel; Nam, Andy; Phelan, Stefan; Liang, Yan; Amin, Amit Dipak; Biermann, Jana; Hibshoosh, Hanina; Veregge, Molly; Kramer, Zachary; Jacobs, Christopher; Yalcin, Yusuf; Phillips, Devan; Slyper, Michal; Subramanian, Ayshwarya; Ashenberg, Orr; Bloom-Ackermann, Zohar; Tran, Victoria M; Gomez, James; Sturm, Alexander; Zhang, Shuting; Fleming, Stephen J; Warren, Sarah; Beechem, Joseph; Hung, Deborah; Babadi, Mehrtash; Padera, Robert F; MacParland, Sonya A; Bader, Gary D; Imad, Nasser; Solomon, Isaac H; Miller, Eric; Riedel, Stefan.
Afiliación
  • Pita-Juarez Y; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Karagkouni D; Harvard Medical School, Boston, MA, USA.
  • Kalavros N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Melms JC; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Niezen S; Harvard Medical School, Boston, MA, USA.
  • Delorey TM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Essene AL; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Brook OR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Pant D; Spatial Technologies Unit, HMS Initiative for RNA Medicine / Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Skelton-Badlani D; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.
  • Naderi P; Columbia Center for Translational Immunology, New York, NY, USA.
  • Huang P; Harvard Medical School, Boston, MA, USA.
  • Pan L; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Hether T; Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Andrews TS; Department of Medicine, Beth Israel Deaconess Medical Center, MA, USA.
  • Ziegler CGK; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Reeves J; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Myloserdnyy A; Department of Medicine, Beth Israel Deaconess Medical Center, MA, USA.
  • Chen R; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Nam A; Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core, Boston, MA, USA.
  • Phelan S; Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Liang Y; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Amin AD; Department of Medicine, Beth Israel Deaconess Medical Center, MA, USA.
  • Biermann J; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Hibshoosh H; Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core, Boston, MA, USA.
  • Veregge M; Harvard Medical School, Boston, MA, USA.
  • Kramer Z; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Jacobs C; Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Yalcin Y; Department of Medicine, Beth Israel Deaconess Medical Center, MA, USA.
  • Phillips D; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Slyper M; Harvard Medical School, Boston, MA, USA.
  • Subramanian A; Harvard Medical School, Boston, MA, USA.
  • Ashenberg O; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Bloom-Ackermann Z; Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Tran VM; Department of Medicine, Beth Israel Deaconess Medical Center, MA, USA.
  • Gomez J; NanoString Technologies, Inc., Seattle, WA, USA.
  • Sturm A; NanoString Technologies, Inc., Seattle, WA, USA.
  • Zhang S; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
  • Fleming SJ; Harvard Medical School, Boston, MA, USA.
  • Warren S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Beechem J; Program in Health Sciences & Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA, USA.
  • Hung D; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Babadi M; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Padera RF; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • MacParland SA; Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA, USA.
  • Bader GD; Harvard Stem Cell Institute, Cambridge, MA, USA.
  • Imad N; Program in Computational & Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Solomon IH; Program in Immunology, Harvard Medical School, Boston, MA, USA.
  • Miller E; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Riedel S; NanoString Technologies, Inc., Seattle, WA, USA.
bioRxiv ; 2022 Oct 28.
Article en En | MEDLINE | ID: mdl-36324805
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos