Relationship between [18F]FDG PET/CT and metabolomics in patients with colorectal cancer.
Metabolomics
; 18(11): 91, 2022 11 11.
Article
en En
| MEDLINE
| ID: mdl-36367606
ABSTRACT
INTRODUCTION:
Advances in metabolomics have significantly improved cancer detection, diagnosis, treatment, and prognosis.OBJECTIVES:
To investigate the relationship between metabolic tumor volume (MTV) using 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/ computed tomography (CT) and metabolomics data in patients with colorectal cancer (CRC).METHODS:
The metabolome in tumor tissues was analyzed using capillary electrophoresis time-of-flight mass spectrometry in 33 patients with newly diagnosed CRC who underwent FDG PET/CT before treatment and had tumor tissue post-surgery. Based on the FDG PET data, MTV was calculated and was dichotomized according to the median value, and tumors were divided into low-MTV and high-MTV tumors. Metabolomics data were compared between the low-MTV and high-MTV tumors.RESULTS:
The levels of most glycolysis-related metabolites were not different between low-MTV and high-MTV tumors. The level of component of the initial part of the tricarboxylic acid (TCA) cycle, citrate, was significantly lower in the high-MTV tumor than in the low-MTV tumor. The TCA intermediate succinate level was significantly higher in the high-MTV tumor than in the low-MTV tumor. In contrast, the TCA intermediate fumarate level was significantly lower in the high-MTV tumor than in the low-MTV tumor. The levels of many amino acids were significantly higher in the high-MTV tumor than in the low-MTV tumor.CONCLUSIONS:
Although preliminary, these results suggest that tumors with high FDG metabolism in CRC may obtain more energy by using a reverse reaction of the TCA cycle and amino-acid metabolism. However, further research is required to clarify this relationship.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Tomografía Computarizada por Tomografía de Emisión de Positrones
Límite:
Humans
Idioma:
En
Revista:
Metabolomics
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón