Mixture effects of tetrodotoxin (TTX) and drugs targeting voltage-gated sodium channels on spontaneous neuronal activity in vitro.

Tukker, Anke M; Vrolijk, Misha F; van Kleef, Regina G D M; Sijm, Dick T H M; Westerink, Remco H S

Tukker, Anke M; Vrolijk, Misha F; van Kleef, Regina G D M; Sijm, Dick T H M; Westerink, Remco H S.

Afiliación

Tukker AM; Neurotoxicology Research Group, Division of Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508 TD Utrecht, the Netherlands.
Vrolijk MF; Faculty of Health, Medicine and Life Sciences, Department of Pharmacology and Toxicology, Maastricht University, 6229 ER Maastricht, the Netherlands.
van Kleef RGDM; Neurotoxicology Research Group, Division of Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508 TD Utrecht, the Netherlands.
Sijm DTHM; Faculty of Health, Medicine and Life Sciences, Department of Pharmacology and Toxicology, Maastricht University, 6229 ER Maastricht, the Netherlands; Office for Risk Assessment and Research, Netherlands Food and Consumer Product Safety Authority (NVWA), 3540 AA Utrecht, the Netherlands.
Westerink RHS; Neurotoxicology Research Group, Division of Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508 TD Utrecht, the Netherlands. Electronic address: R.Westerink@uu.nl.

Toxicol Lett ; 373: 53-61, 2023 Jan 15.

Article en En | MEDLINE | ID: mdl-36375636

Asunto(s)

Tetrodotoxina; Canales de Sodio Activados por Voltaje; Animales; Humanos; Ratas; Carbamazepina/farmacología; Flecainida; Lidocaína/toxicidad; Riluzol/farmacología; Tetrodotoxina/farmacología; Tetrodotoxina/toxicidad; Canales de Sodio Activados por Voltaje/efectos de los fármacos

Palabras clave

Human induced pluripotent stem cell-derived neuronal co-cultures; In vitro hazard characterisation; Microelectrode array (MEA) recordings; Pharmacodynamic mixture interactions; Rat primary cortical cultures; Risk assessment

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tetrodotoxina / Canales de Sodio Activados por Voltaje Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Toxicol Lett Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos

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