Outcomes in participants with failure of initial antibacterial therapy for hospital-acquired/ventilator-associated bacterial pneumonia prior to enrollment in the randomized, controlled phase 3 ASPECT-NP trial of ceftolozane/tazobactam versus meropenem.

Kollef, Marin H; Timsit, Jean-François; Martin-Loeches, Ignacio; Wunderink, Richard G; Huntington, Jennifer A; Jensen, Erin H; Yu, Brian; Bruno, Christopher J

Kollef, Marin H; Timsit, Jean-François; Martin-Loeches, Ignacio; Wunderink, Richard G; Huntington, Jennifer A; Jensen, Erin H; Yu, Brian; Bruno, Christopher J.

Afiliación

Kollef MH; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO, USA.
Timsit JF; Intensive Care Medicine Department, Université Paris Diderot and Hôpital Bichat, Paris, France.
Martin-Loeches I; Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James' Hospital, Dublin, Ireland.
Wunderink RG; Hospital Clinic, Universitat de Barcelona, IDIBAPS, CIBERES, Barcelona, Spain.
Huntington JA; Pulmonary and Critical Care Division, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jensen EH; Merck & Co., Inc., Rahway, NJ, USA.
Yu B; Merck & Co., Inc., Rahway, NJ, USA.
Bruno CJ; Merck & Co., Inc., Rahway, NJ, USA.

Crit Care ; 26(1): 373, 2022 12 01.

Article en En | MEDLINE | ID: mdl-36457059

Asunto(s)

Neumonía Bacteriana; Neumonía Asociada al Ventilador; Adulto; Humanos; Antibacterianos/uso terapéutico; Cefalosporinas/farmacología; Cefalosporinas/uso terapéutico; Hospitales; Meropenem/farmacología; Meropenem/uso terapéutico; Monobactamas; Neumonía Bacteriana/tratamiento farmacológico; Tazobactam/farmacología; Tazobactam/uso terapéutico; Vasoconstrictores; Ventiladores Mecánicos

Palabras clave

All-cause mortality; Clinical response; Failing prior antibacterial therapy; HABP; Mechanical ventilation; Multivariable analysis; Nosocomial pneumonia; Refractory; VABP

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neumonía Bacteriana / Neumonía Asociada al Ventilador Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Crit Care Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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