Novel variants in GABA<sub>A</sub> receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy.

Chakraborty, Aphrodite; Dey, Soumil; Kumar, Krishan; Dixit, Aparna B; Tripathi, Manjari; Sharma, Mehar C; Chandra, P Sarat; Banerjee, Jyotirmoy

Novel variants in GABA_A receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy.

Chakraborty, Aphrodite; Dey, Soumil; Kumar, Krishan; Dixit, Aparna B; Tripathi, Manjari; Sharma, Mehar C; Chandra, P Sarat; Banerjee, Jyotirmoy.

Afiliación

Chakraborty A; Department of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Dey S; Department of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Kumar K; Dr. B.R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi, New Delhi, India.
Dixit AB; Dr. B.R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi, New Delhi, India. Electronic address: aparnabanerjeedixit@gmail.com.
Tripathi M; Department of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Sharma MC; Department of Pathology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Chandra PS; Department of Neurosurgery, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Banerjee J; Department of Biophysics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Electronic address: jyotirmoybanerjee1@gmail.com.

Epilepsy Res ; 189: 107056, 2023 Jan.

Article en En | MEDLINE | ID: mdl-36469977

Asunto(s)

Epilepsia Refractaria; Epilepsia del Lóbulo Temporal; Humanos; Benzodiazepinas/uso terapéutico; Epilepsia Refractaria/tratamiento farmacológico; Epilepsia Refractaria/genética; Epilepsia Refractaria/cirugía; Epilepsia del Lóbulo Temporal/patología; Hipocampo/patología; Receptores de GABA-A/genética; Receptores de GABA-A/metabolismo; Convulsiones/complicaciones

Palabras clave

Benzodiazepine resistance; Drug-resistant epilepsy (DRE); Focal Cortical Dysplasia (FCD); GABA(A) receptor; Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS); Patch-clamp electrophysiology; Sanger sequencing

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Epilepsia del Lóbulo Temporal / Epilepsia Refractaria Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Epilepsy Res Asunto de la revista: CEREBRO / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: India

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