Your browser doesn't support javascript.
loading
The Human Respiratory Microbiome: Current Understandings and Future Directions.
Zhao, Lan; Luo, Jun-Li; Ali, Mohammed Khadem; Spiekerkoetter, Edda; Nicolls, Mark R.
Afiliación
  • Zhao L; Division of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine, and.
  • Luo JL; Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California.
  • Ali MK; VA Palo Alto Health Care System, Palo Alto, California; and.
  • Spiekerkoetter E; The Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, China.
  • Nicolls MR; Division of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine, and.
Am J Respir Cell Mol Biol ; 68(3): 245-255, 2023 03.
Article en En | MEDLINE | ID: mdl-36476129
Microorganisms colonize the human body. The lungs and respiratory tract, previously believed to be sterile, harbor diverse microbial communities and the genomes of bacteria (bacteriome), viruses (virome), and fungi (mycobiome). Recent advances in amplicon and shotgun metagenomic sequencing technologies and data-analyzing methods have greatly aided the identification and characterization of microbial populations from airways. The respiratory microbiome has been shown to play roles in human health and disease and is an area of rapidly emerging interest in pulmonary medicine. In this review, we provide updated information in the field by focusing on four lung conditions, including asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis. We evaluate gut, oral, and upper airway microbiomes and how they contribute to lower airway flora. The discussion is followed by a systematic review of the lower airway microbiome in health and disease. We conclude with promising research avenues and implications for evolving therapeutics.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Asma / Fibrosis Quística / Enfermedad Pulmonar Obstructiva Crónica / Microbiota Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Am J Respir Cell Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Asma / Fibrosis Quística / Enfermedad Pulmonar Obstructiva Crónica / Microbiota Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Am J Respir Cell Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article