Gold-Catalyzed [4 + 1] Heterocyclization of Hydroxamic Acid and Nonactivated Alkyne: A Protocol to Construct 5-Methyl-1,4,2-dioxazole.
J Org Chem
; 88(1): 433-441, 2023 01 06.
Article
en En
| MEDLINE
| ID: mdl-36485008
ABSTRACT
A novel gold-catalyzed [4 + 1] heterocyclization of nonactivated alkyne and hydroxamic acid is developed for the regiospecific synthesis of 5-methyl-1,4,2-dioxazole, which is an important structural motif in various bioactive molecules. The current methodology is characterized by high efficiency, simple operation, mild reaction conditions, and good functional group compatibility. Moreover, gram-scale synthesis and synthetic application toward bioactive molecular skeletons have been realized.
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Bases de datos:
MEDLINE
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Alquinos
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En
Revista:
J Org Chem
Año:
2023
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Article
País de afiliación:
China