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HIV-Associated Microbial Translocation May Affect Cytokine Production of CD56bright NK Cells via Stimulation of Monocytes.
ToVinh, Michael; Hörr, Gregor; Hoffmeister, Christoph; Dobrikova, Kristiyana; Gotter, Christina; Raabe, Jan; Kaiser, Kim M; Ahmad, Sarah; Finnemann, Claudia; Matejec, Eyleen; Hack, Gudrun; Bischoff, Jenny; Rieke, Gereon J; Schwarze-Zander, Carolynne; Boesecke, Christoph; van Bremen, Kathrin; Wasmuth, Jan-Christian; Eis-Hübinger, Anna M; Streeck, Hendrik; Verhasselt, Hedda L; Oldenburg, Johannes; Strassburg, Christian P; Rockstroh, Jürgen K; Spengler, Ulrich; Krämer, Benjamin; Nattermann, Jacob.
Afiliación
  • ToVinh M; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Hörr G; German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.
  • Hoffmeister C; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Dobrikova K; German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.
  • Gotter C; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Raabe J; German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.
  • Kaiser KM; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Ahmad S; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Finnemann C; German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.
  • Matejec E; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Hack G; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Bischoff J; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Rieke GJ; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Schwarze-Zander C; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Boesecke C; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • van Bremen K; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Wasmuth JC; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Eis-Hübinger AM; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Streeck H; German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.
  • Verhasselt HL; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Oldenburg J; German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.
  • Strassburg CP; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Rockstroh JK; German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.
  • Spengler U; Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Krämer B; German Center for Infection Research, Thematical Translation Units HIV, Cologne/Bonn, Germany.
  • Nattermann J; Institute of Virology, University Hospital, University of Bonn, Bonn, Germany.
J Infect Dis ; 227(4): 577-582, 2023 02 14.
Article en En | MEDLINE | ID: mdl-36520641
ABSTRACT
The mechanisms involved in HIV-associated natural killer (NK) cell impairment are still incompletely understood. We observed HIV infection to be associated with increased plasma levels of IFABP, a marker for gut epithelial barrier dysfunction, and LBP, a marker for microbial translocation. Both IFABP and LBP plasma concentrations were inversely correlated with NK cell interferon-γ production, suggesting microbial translocation to modulate NK cell functions. Accordingly, we found lipopolysaccharide to have an indirect inhibitory effect on NK cells via triggering monocytes' transforming growth factor-ß production. Taken together, our data suggest increased microbial translocation to be involved in HIV-associated NK cell dysfunction.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Monocitos / Infecciones por VIH Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Monocitos / Infecciones por VIH Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Alemania