Glycosyl Radical-Based Synthesis of C-Glycoamino Acids and C-Glycopeptides.
Chemistry
; 29(21): e202203689, 2023 Apr 13.
Article
en En
| MEDLINE
| ID: mdl-36586132
ABSTRACT
Radical-based reactions usually exhibit excellent functional-group compatibilities due to their mild initiation conditions. Glycosyl radical involved C-glycosylation modifications are important strategies to achieve highly regio- and chemoselective constructions of C-glycosidic bonds or C-glycoside linkages of peptides and proteins. In this Concept, we cover recent developments in glycosyl radical-based synthesis of unnatural amino acids and late-stage modification of peptides and proteins, and provide a preliminary outlook on the possible development of this direction in the future.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glicopéptidos
/
Aminoácidos
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2023
Tipo del documento:
Article