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Oxytocin signaling is necessary for synaptic maturation of adult-born neurons.
Pekarek, Brandon T; Kochukov, Mikhail; Lozzi, Brittney; Wu, Timothy; Hunt, Patrick J; Tepe, Burak; Hanson Moss, Elizabeth; Tantry, Evelyne K; Swanson, Jessica L; Dooling, Sean W; Patel, Mayuri; Belfort, Benjamin D W; Romero, Juan M; Bao, Suyang; Hill, Matthew C; Arenkiel, Benjamin R.
Afiliación
  • Pekarek BT; Genetics and Genomics Graduate Program, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Kochukov M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Lozzi B; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030, USA.
  • Wu T; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030, USA.
  • Hunt PJ; Department of Anesthesiology, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Tepe B; Genetics and Genomics Graduate Program, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Hanson Moss E; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Tantry EK; Genetics and Genomics Graduate Program, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Swanson JL; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Dooling SW; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030, USA.
  • Patel M; Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Belfort BDW; Genetics and Genomics Graduate Program, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Romero JM; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Bao S; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030, USA.
  • Hill MC; Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas 77030, USA.
  • Arenkiel BR; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Genes Dev ; 36(21-24): 1100-1118, 2022.
Article en En | MEDLINE | ID: mdl-36617877
ABSTRACT
Neural circuit plasticity and sensory response dynamics depend on forming new synaptic connections. Despite recent advances toward understanding the consequences of circuit plasticity, the mechanisms driving circuit plasticity are unknown. Adult-born neurons within the olfactory bulb have proven to be a powerful model for studying circuit plasticity, providing a broad and accessible avenue into neuron development, migration, and circuit integration. We and others have shown that efficient adult-born neuron circuit integration hinges on presynaptic activity in the form of diverse signaling peptides. Here, we demonstrate a novel oxytocin-dependent mechanism of adult-born neuron synaptic maturation and circuit integration. We reveal spatial and temporal enrichment of oxytocin receptor expression within adult-born neurons in the murine olfactory bulb, with oxytocin receptor expression peaking during activity-dependent integration. Using viral labeling, confocal microscopy, and cell type-specific RNA-seq, we demonstrate that oxytocin receptor signaling promotes synaptic maturation of newly integrating adult-born neurons by regulating their morphological development and expression of mature synaptic AMPARs and other structural proteins.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxitocina / Receptores de Oxitocina Límite: Animals Idioma: En Revista: Genes Dev Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxitocina / Receptores de Oxitocina Límite: Animals Idioma: En Revista: Genes Dev Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos