MicroRNA-30e-3p reduces coronary microembolism-induced cardiomyocyte pyroptosis and inflammation by sequestering HDAC2 from the <i>SMAD7</i> promoter.

Dai, Rixin; Ren, Yanling; Lv, Xiangwei; Chang, Chen; He, Shirong; Li, Quanzhong; Yang, Xiheng; Ren, Lei; Wei, Riming; Su, Qiang

MicroRNA-30e-3p reduces coronary microembolism-induced cardiomyocyte pyroptosis and inflammation by sequestering HDAC2 from the SMAD7 promoter.

Dai, Rixin; Ren, Yanling; Lv, Xiangwei; Chang, Chen; He, Shirong; Li, Quanzhong; Yang, Xiheng; Ren, Lei; Wei, Riming; Su, Qiang.

Afiliación

Dai R; Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
Ren Y; Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
Lv X; Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
Chang C; Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
He S; Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
Li Q; Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
Yang X; Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
Ren L; Department of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
Wei R; College of Biotechnology, Guilin Medical University, Guilin, People's Republic of China.
Su Q; Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.

Am J Physiol Cell Physiol ; 324(2): C222-C235, 2023 02 01.

Article en En | MEDLINE | ID: mdl-36622073

Asunto(s)

MicroARNs; Miocitos Cardíacos; Ratas; Animales; Miocitos Cardíacos/metabolismo; MicroARNs/genética; MicroARNs/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/genética; Interleucina-18/metabolismo; beta Catenina/metabolismo; Piroptosis/genética; Inflamación; ARN Mensajero; Caspasas/metabolismo; Proteína smad7/genética; Proteína smad7/metabolismo; Histona Desacetilasa 2/genética

Palabras clave

HDAC2; SMAD7; coronary microembolism; miR-30e-3p; pyroptosis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Miocitos Cardíacos / MicroARNs Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Am J Physiol Cell Physiol Asunto de la revista: FISIOLOGIA Año: 2023 Tipo del documento: Article

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