Loss of a gluconeogenic muscle enzyme contributed to adaptive metabolic traits in hummingbirds.
Science
; 379(6628): 185-190, 2023 01 13.
Article
en En
| MEDLINE
| ID: mdl-36634192
ABSTRACT
Hummingbirds possess distinct metabolic adaptations to fuel their energy-demanding hovering flight, but the underlying genomic changes are largely unknown. Here, we generated a chromosome-level genome assembly of the long-tailed hermit and screened for genes that have been specifically inactivated in the ancestral hummingbird lineage. We discovered that FBP2 (fructose-bisphosphatase 2), which encodes a gluconeogenic muscle enzyme, was lost during a time period when hovering flight evolved. We show that FBP2 knockdown in an avian muscle cell line up-regulates glycolysis and enhances mitochondrial respiration, coincident with an increased mitochondria number. Furthermore, genes involved in mitochondrial respiration and organization have up-regulated expression in hummingbird flight muscle. Together, these results suggest that FBP2 loss was likely a key step in the evolution of metabolic muscle adaptations required for true hovering flight.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Aves
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Adaptación Fisiológica
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Fructosa-Bifosfatasa
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Músculo Esquelético
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Vuelo Animal
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Gluconeogénesis
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania