Diclofenac Disrupts the Circadian Clock and through Complex Cross-Talks Aggravates Immune-Mediated Liver Injury-A Repeated Dose Study in Minipigs for 28 Days.

Selvaraj, Saravanakumar; Oh, Jung-Hwa; Yoon, Seokjoo; Borlak, Jürgen

Selvaraj, Saravanakumar; Oh, Jung-Hwa; Yoon, Seokjoo; Borlak, Jürgen.

Afiliación

Selvaraj S; Centre for Pharmacology and Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Oh JH; Centre for Pharmacology and Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Yoon S; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Borlak J; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.

Int J Mol Sci ; 24(2)2023 01 11.

Article en En | MEDLINE | ID: mdl-36674967

Asunto(s)

Relojes Circadianos; Animales; Porcinos; Relojes Circadianos/fisiología; Ritmo Circadiano/fisiología; Diclofenaco/farmacología; Porcinos Enanos; Hígado/metabolismo; Proteínas CLOCK/metabolismo; Transducción de Señal

Palabras clave

cellular metabolism; diclofenac; drug-induced liver injury; genomics; hepatitis; histopathology; immunohistochemistry; liver clock; liver pathology; transcriptional networks

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Relojes Circadianos Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Alemania

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