Co-amorphous formulation of dipyridamole with p-hydroxybenzoic acid: Underlying molecular mechanisms, physical stability, dissolution behavior and pharmacokinetic study.

Guo, Wei; Dong, Xueqing; Li, Yuanchun; Li, Congwei; Tian, Yawen; Gao, Huibing; Li, Tiantian; Zhu, Hanruo; Wang, Jing; Yang, Caiqin

Guo, Wei; Dong, Xueqing; Li, Yuanchun; Li, Congwei; Tian, Yawen; Gao, Huibing; Li, Tiantian; Zhu, Hanruo; Wang, Jing; Yang, Caiqin.

Afiliación

Guo W; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Dong X; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Li Y; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Li C; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Tian Y; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Gao H; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Li T; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Zhu H; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Wang J; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China. Electronic address: jingwang@home.ipe.ac.cn.
Yang C; School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China. Electronic address: yangcaiqin@hebmu.edu.cn.

Eur J Pharm Biopharm ; 184: 139-149, 2023 Mar.

Article en En | MEDLINE | ID: mdl-36709922

Asunto(s)

Dipiridamol; Ratones; Animales; Solubilidad; Temperatura de Transición; Difracción de Rayos X; Rastreo Diferencial de Calorimetría; Estabilidad de Medicamentos; Espectroscopía Infrarroja por Transformada de Fourier

Palabras clave

Co-amorphous system; Dipyridamole; Glass transition kinetics; Intermolecular interactions; Pharmacokinetic study; Physicochemical properties

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Dipiridamol Límite: Animals Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article

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