Multicenter prospective observational study of dupilumab-induced ocular events in atopic dermatitis patients.
J Eur Acad Dermatol Venereol
; 37(5): 1056-1063, 2023 May.
Article
en En
| MEDLINE
| ID: mdl-36732052
ABSTRACT
BACKGROUND:
Although ocular adverse events are frequent in AD patients treated with dupilumab, their characterization remains limited due to a lack of prospective studies with a systematic ophthalmological examination.OBJECTIVE:
To examine the incidence, characteristics and risk factors of dupilumab-induced ocular adverse events.METHODS:
A prospective, multicenter, and real-life study in adult AD patients treated with dupilumab.RESULTS:
At baseline, 27 out of 181 patients (14.9%) had conjunctivitis. At week 16 (W16), 25 out of 27 had improved their conjunctivitis and 2 remained stable and 34 out of 181 patients (18.7%) had dupilumab-induced blepharoconjunctivitis either de novo (n = 32) or worsening of underlying blepharoconjunctivitis (n = 2). Most events (27/34; 79.4%) were moderate. A multivariate analysis showed that head and neck AD (OR = 7.254; 95%CI [1.938-30.07]; p = 0.004), erythroderma (OR = 5.635; 95%CI [1.635-21.50]; p = 0.007) and the presence of dry eye syndrome at baseline (OR = 3.51; 95%CI [3.158-13.90]; p = 0.031) were independent factors associated with dupilumab-induced blepharoconjunctivitis.LIMITATIONS:
Our follow-up period was 16 weeks and some late-onset time effects may still occur.CONCLUSION:
This study showed that most dupilumab-induced blepharoconjunctivitis cases are de novo. AD severity and conjunctivitis at baseline were not found to be associated risk factors in this study.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Conjuntivitis
/
Dermatitis Atópica
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
Idioma:
En
Revista:
J Eur Acad Dermatol Venereol
Asunto de la revista:
DERMATOLOGIA
/
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Año:
2023
Tipo del documento:
Article
País de afiliación:
Francia