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A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study.
Swen, Jesse J; van der Wouden, Cathelijne H; Manson, Lisanne En; Abdullah-Koolmees, Heshu; Blagec, Kathrin; Blagus, Tanja; Böhringer, Stefan; Cambon-Thomsen, Anne; Cecchin, Erika; Cheung, Ka-Chun; Deneer, Vera Hm; Dupui, Mathilde; Ingelman-Sundberg, Magnus; Jonsson, Siv; Joefield-Roka, Candace; Just, Katja S; Karlsson, Mats O; Konta, Lidija; Koopmann, Rudolf; Kriek, Marjolein; Lehr, Thorsten; Mitropoulou, Christina; Rial-Sebbag, Emmanuelle; Rollinson, Victoria; Roncato, Rossana; Samwald, Matthias; Schaeffeler, Elke; Skokou, Maria; Schwab, Matthias; Steinberger, Daniela; Stingl, Julia C; Tremmel, Roman; Turner, Richard M; van Rhenen, Mandy H; Dávila Fajardo, Cristina L; Dolzan, Vita; Patrinos, George P; Pirmohamed, Munir; Sunder-Plassmann, Gere; Toffoli, Giuseppe; Guchelaar, Henk-Jan.
Afiliación
  • Swen JJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.
  • van der Wouden CH; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.
  • Manson LE; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.
  • Abdullah-Koolmees H; Division Laboratories, Pharmacy and Biomedical Genetics, Hospital Pharmacy, University Medical Centre Utrecht, Utrecht, Netherlands.
  • Blagec K; Centre for Medical Statistics, Informatics and Intelligent Systems, Institute of Artificial Intelligence, Medical University of Vienna, Vienna, Austria.
  • Blagus T; Pharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Böhringer S; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands; Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands.
  • Cambon-Thomsen A; CNRS, Centre for Epidemiology and Research in Population health (CERPOP), Université de Toulouse, Inserm, UPS, Toulouse, France.
  • Cecchin E; Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
  • Cheung KC; Medicines Information Centre, Royal Dutch Pharmacists Association (KNMP), The Hague, Netherlands.
  • Deneer VH; Division Laboratories, Pharmacy and Biomedical Genetics, Hospital Pharmacy, University Medical Centre Utrecht, Utrecht, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Netherlands.
  • Dupui M; Service de pharmacologie médicale et clinique, CEIP-addictovigilance de Toulouse, faculté de médecine, CHU, Toulouse, France.
  • Ingelman-Sundberg M; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, Stockholm, Sweden.
  • Jonsson S; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
  • Joefield-Roka C; Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.
  • Just KS; Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Germany.
  • Karlsson MO; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
  • Konta L; Bio.logis Digital Health, Frankfurt am Main, Germany.
  • Koopmann R; Bio.logis Digital Health, Frankfurt am Main, Germany; Diagnosticum Centre for Humangenetics, Frankfurt am Main, Germany.
  • Kriek M; Department of Clinical Genetics, Leiden University Medical Centre, Leiden, Netherlands.
  • Lehr T; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
  • Mitropoulou C; The Golden Helix Foundation, London, UK; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, Abu Dhabi, United Arab Emirates.
  • Rial-Sebbag E; Universite de Toulouse III Paul Sabatier, Toulouse, France.
  • Rollinson V; Department of Pharmacology and Therapeutics, Wolfson Centre for Personalised Medicine, The University of Liverpool, Liverpool, UK.
  • Roncato R; Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
  • Samwald M; Centre for Medical Statistics, Informatics and Intelligent Systems, Institute of Artificial Intelligence, Medical University of Vienna, Vienna, Austria.
  • Schaeffeler E; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; iFIT Cluster of Excellence (EXC2180)-Image Guided and Functionally Instructed Tumour Therapies, University of Tuebingen, Tuebingen, Germany.
  • Skokou M; University of Patras School of Health Sciences, Department of Pharmacy, Division of Pharmacology and Biosciences, Laboratory of Pharmacogenomics and Individualised Therapy, Patras, Greece.
  • Schwab M; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; iFIT Cluster of Excellence (EXC2180)-Image Guided and Functionally Instructed Tumour Therapies, University of Tuebingen, Tuebingen, Germany; Department of Clinical Pharmacology, University of Tuebingen, Tuebingen, Ger
  • Steinberger D; Bio.logis Digital Health, Frankfurt am Main, Germany; Diagnosticum Centre for Humangenetics, Frankfurt am Main, Germany.
  • Stingl JC; Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Germany.
  • Tremmel R; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
  • Turner RM; Department of Pharmacology and Therapeutics, Wolfson Centre for Personalised Medicine, The University of Liverpool, Liverpool, UK.
  • van Rhenen MH; Medicines Information Centre, Royal Dutch Pharmacists Association (KNMP), The Hague, Netherlands.
  • Dávila Fajardo CL; Clinical Pharmacy Department, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria Granada, Granada, Spain.
  • Dolzan V; Pharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Patrinos GP; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, Abu Dhabi, United Arab Emirates; Zayed Centre for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, Abu Dhabi, United Arab Emirates;
  • Pirmohamed M; Department of Pharmacology and Therapeutics, Wolfson Centre for Personalised Medicine, The University of Liverpool, Liverpool, UK.
  • Sunder-Plassmann G; Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.
  • Toffoli G; Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
  • Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands. Electronic address: h.j.guchelaar@lumc.nl.
Lancet ; 401(10374): 347-356, 2023 02 04.
Article en En | MEDLINE | ID: mdl-36739136
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Farmacogenética / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Lancet Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Farmacogenética / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Lancet Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos