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A SNP in the ovine cathepsin K (CTSK) gene is associated with yearling growth performance in a crossbred sheep population.
Pasandideh, Majid; Harkinezhad, Taher; Mohammadi, Leila.
Afiliación
  • Pasandideh M; Department of Animal Science, Faculty of Animal and Aquatic Science, Sari Agricultural Sciences and Natural Resources University, Sari, Iran.
  • Harkinezhad T; Department of Animal Science, Faculty of Agriculture, University of Zanjan, Zanjan, Iran.
  • Mohammadi L; Department of Animal Science, Faculty of Agriculture, University of Zanjan, Zanjan, Iran.
Anim Biotechnol ; 34(9): 5155-5159, 2023 Dec.
Article en En | MEDLINE | ID: mdl-36752216
Cathepsin K (CTSK) is a lysosomal protease existent in the skeletal muscles which is involved in biochemical processes related to obesity. Several studies have reported the effects of CTSK gene on body weight and fat deposition in human, mice and pigs. However, information about its structure and functions in sheep is very limited. Thus, this study was performed to evaluate the association between CTSK gene variants and yearling growth performance in Afshari × Booroola-Merino crossbred sheep. A fragment of 500 bp in exon 6 and partial of intron 5 of CTSK gene was amplified with polymerase chain reaction (PCR). All animals were genotyped by single-stranded conformation polymorphism (SSCP) and further confirmed by sequencing. Association analysis using a fixed linear model indicated that g.106510225G > A SNP was significantly related to average daily weight gain (ADWG) per year, fat-tail weight to carcass weight ratio (FW/CW), muscle thickness (MT) and muscle cross-sectional area (MCSA) of animals (p < 0.05). Due to the low polymorphic information content (PIC <0.25) for targeted locus in studied population, more association studies are needed to confirm the CTSK gene effects on growth traits in sheep.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Anim Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Irán

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Anim Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Irán