Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline-deficient l-amino acid-defined diet prevents hepatocarcinogenesis in mice.

Gnocchi, Davide; Afonso, Marta B; Cavalluzzi, Maria Maddalena; Lentini, Giovanni; Ingravallo, Giuseppe; Sabbà, Carlo; Rodrigues, Cecilia M P; Mazzocca, Antonio

Gnocchi, Davide; Afonso, Marta B; Cavalluzzi, Maria Maddalena; Lentini, Giovanni; Ingravallo, Giuseppe; Sabbà, Carlo; Rodrigues, Cecilia M P; Mazzocca, Antonio.

Afiliación

Gnocchi D; Interdisciplinary Department of Medicine, University of Bari School of Medicine, Bari, Italy.
Afonso MB; Research Institute for Medicines (iMed. ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Cavalluzzi MM; Department of Pharmacy-Drug Sciences, University of Bari, Bari, Italy.
Lentini G; Department of Pharmacy-Drug Sciences, University of Bari, Bari, Italy.
Ingravallo G; Department of Precision and Regenerative Medicine and Ionian Area, Section of Pathology, University of Bari School of Medicine, Bari, Italy.
Sabbà C; Interdisciplinary Department of Medicine, University of Bari School of Medicine, Bari, Italy.
Rodrigues CMP; Research Institute for Medicines (iMed. ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Mazzocca A; Interdisciplinary Department of Medicine, University of Bari School of Medicine, Bari, Italy.

Mol Carcinog ; 62(5): 577-582, 2023 05.

Article en En | MEDLINE | ID: mdl-36752344

Asunto(s)

Carcinoma Hepatocelular; Deficiencia de Colina; Neoplasias Hepáticas; Ratones; Animales; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/prevención & control; Carcinoma Hepatocelular/metabolismo; Aminoácidos; Receptores del Ácido Lisofosfatídico/genética; Receptores del Ácido Lisofosfatídico/metabolismo; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/prevención & control; Neoplasias Hepáticas/metabolismo; Colina/farmacología; Deficiencia de Colina/complicaciones; Deficiencia de Colina/metabolismo; Dieta/efectos adversos; Carcinogénesis/genética

Palabras clave

LPAR6; NAFLD; NASH; hepatic metabolism; hepatocellular carcinoma; lysophosphatidic acid

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Deficiencia de Colina / Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Animals Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Italia

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