Total Synthesis of Caldorazole, a Potent Mitochondrial Respiratory Chain Inhibitor without Chiral Centers.
J Org Chem
; 88(5): 3208-3216, 2023 03 03.
Article
en En
| MEDLINE
| ID: mdl-36800251
ABSTRACT
Caldorazole (1) is a novel polyketide that was isolated from a marine cyanobacterium in 2022. It is a unique natural product that exhibits potent inhibitory activity against mitochondrial respiratory chain complex I despite having no chiral centers. To establish a method for obtaining caldorazole without relying on biological resources and for constructing a useful synthetic route for studies of its structure-activity relationship, we achieved the first total synthesis of caldorazole using a convergent synthetic route.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cianobacterias
/
Policétidos
Idioma:
En
Revista:
J Org Chem
Año:
2023
Tipo del documento:
Article
País de afiliación:
Japón