Stereoselective Syntheses of Masked ß-Amino Acid Containing Phthalides.
Helv Chim Acta
; 105(11): e202200110, 2022 Nov.
Article
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| MEDLINE
| ID: mdl-36845268
ABSTRACT
We herein report a protocol for the asymmetric aldol-initiated cascade addition of isoxazolidin-5-ones to ortho-cyanobenzaldehydes by using Takemoto's bifunctional organocatalyst. This approach allows for the synthesis of various novel ß2,2-amino acid-phthalide conjugates with good enantio- and diastereoselectivities in reasonable yields and the further ring-opening of these compounds to acyclic carboxylic acid derivatives was demonstrated too.
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MEDLINE
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En
Revista:
Helv Chim Acta
Año:
2022
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Article
País de afiliación:
Austria