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Pembrolizumab plus pemetrexed-carboplatin combination in first-line treatment of advanced non-squamous non-small cell lung cancer: a multicenter real-life study (CAP29).
Renaud, Emmanuelle; Ricordel, Charles; Corre, Romain; Leveiller, Guillaume; Gadby, Florence; Babey, Hélène; Annic, Josselin; Lucia, François; Bourbonne, Vincent; Robinet, Gilles; Descourt, Renaud; Orione, Charles; Quéré, Gilles; Geier, Margaux.
Afiliación
  • Renaud E; Department of Medical Oncology, CHRU Morvan, University Hospital of Brest, Brest, France.
  • Ricordel C; Department of Pulmonary Diseases, CHU Pontchaillou, University Hospital of Rennes, Rennes, France.
  • Corre R; Department of Pulmonary Diseases, CH Cornouaille, Quimper, France.
  • Leveiller G; Department of Pulmonary Diseases, CH Yves Le Foll, Saint-Brieuc, France.
  • Gadby F; Department of Pulmonary Diseases, Hospital of Morlaix, Morlaix, France.
  • Babey H; Department of Medical Oncology, Hospital of Landerneau, Landerneau, France.
  • Annic J; Department of Medical Oncology, CHRU Morvan, University Hospital of Brest, Brest, France.
  • Lucia F; Department of Radiation Oncology, CHRU Morvan, University Hospital of Brest, Brest, France.
  • Bourbonne V; Department of Radiation Oncology, CHRU Morvan, University Hospital of Brest, Brest, France.
  • Robinet G; Department of Medical Oncology, CHRU Morvan, University Hospital of Brest, Brest, France.
  • Descourt R; Department of Medical Oncology, CHRU Morvan, University Hospital of Brest, Brest, France.
  • Orione C; Department of Pulmonary Diseases, CHRU Cavale Blanche University Hospital of Brest, Brest, France.
  • Quéré G; Department of Medical Oncology, CHRU Morvan, University Hospital of Brest, Brest, France.
  • Geier M; Department of Medical Oncology, CHRU Morvan, University Hospital of Brest, Brest, France.
Transl Lung Cancer Res ; 12(2): 266-276, 2023 Feb 28.
Article en En | MEDLINE | ID: mdl-36895931
Background: Pembrolizumab combined with chemotherapy is now first-line standard of care in advanced non-small cell lung cancer. This real-life study aimed to assess efficacy and safety of carboplatin-pemetrexed plus pembrolizumab in advanced non-squamous non-small cell lung cancer. Methods: CAP29 is a retrospective, observational, multicenter real-life study conducted in 6 French centers. We evaluated efficacy of first-line setting chemotherapy plus pembrolizumab (November 2019 to September 2020) in advanced (stage III-IV) non-squamous non-small cell lung cancer patients without targetable alterations. Primary endpoint was progression-free survival. Secondary endpoints were overall survival, objective response rate and safety. Results: With a median follow-up of 4.5 months (0 to 22 months), a total of 121 patients were included. Baseline characteristics were: median age of 59.8 years with 7.4% ≥75 years, 58.7% of males, 91.8% PS 0-1, 87.6% of stage IV with ≥3 metastatic sites in 62% of cases. Patients had brain and liver metastases in 24% and 15.7% of cases, respectively. PD-L1 was <1% (44.6%), 1-49% (28.1%) and ≥50% (21.5%). Median progression-free survival and overall survival achieved 9 and 20.6 months, respectively. Objective response rate was 63.7% with 7 prolonged complete responses. Survival benefit seemed to be correlated with PD-L1 expression. Brain and liver metastases were not statistically associated with decreased overall survival. Most common adverse events were asthenia (76%), anemia (61.2%), nausea (53.7%), decreased appetite (37.2%) and liver cytolysis (34.7%). Renal and hepatic disorders were the main causes of pemetrexed discontinuation. Grade 3-4 adverse events concerned 17.5% of patients. Two treatment-related deaths were reported. Conclusions: First-line pembrolizumab plus chemotherapy confirmed real-life efficacy for patients with advanced non-squamous non-small cell lung cancer. With median progression-free survival and overall survival of 9.0 and 20.6 months, respectively and no new safety signal, our real-life data are very close to results provided by clinical trials, confirming the benefit and the manageable toxicity profile of this combination.
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Transl Lung Cancer Res Año: 2023 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Transl Lung Cancer Res Año: 2023 Tipo del documento: Article País de afiliación: Francia