Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials.
Medicine (Baltimore)
; 102(10): e33101, 2023 Mar 10.
Article
en En
| MEDLINE
| ID: mdl-36897714
ABSTRACT
BACKGROUND:
Postoperative pain is one of the most feared complications of total knee arthroplasty. Recently, randomized controlled trials have compared the efficacy of duloxetine in patients undergoing total knee arthroplasty. However, there is no definite answer as to the efficacy and safety of duloxetine.METHODS:
Randomized controlled trials about relevant studies were searched from PubMed (1996 to July 2022), Embase (1996 to July 2022), and Cochrane Library (CENTRAL, July 2022).RESULTS:
Six high-quality studies containing 532 patients met the inclusion criteria. Results show patients in the duloxetine group had better performance in terms of visual analog scale (P < .05), equivalent morphine consumption (P < .05), and length of stay (P < .05).CONCLUSION:
Duloxetine can be used to reduce pain after knee arthroplasty in selected patients.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Artroplastia de Reemplazo de Rodilla
/
Manejo del Dolor
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2023
Tipo del documento:
Article