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TCR sequencing: applications in immuno-oncology research.
Sanromán, Á F; Joshi, K; Au, L; Chain, B; Turajlic, S.
Afiliación
  • Sanromán ÁF; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.
  • Joshi K; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK.
  • Au L; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London, UK.
  • Chain B; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.
  • Turajlic S; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Immunooncol Technol ; 17: 100373, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36908996
ABSTRACT
•T-cell receptor (TCR) interaction with major histocompatibility complex-antigen complexes leads to antitumour responses.•TCR sequencing analysis allows characterisation of T cells that recognise tumour neoantigens.•T-cell clonal revival and clonal replacement potentially underpin immunotherapy responses.
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Immunooncol Technol Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Immunooncol Technol Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido