JAK/STAT signaling pathway and its regulation on insect immunity.
Yi Chuan
; 45(3): 229-236, 2023 Mar 20.
Article
en En
| MEDLINE
| ID: mdl-36927649
ABSTRACT
JAK/STAT signaling pathway is involved in important biological processes, such as cell growth, differentiation, apoptosis and immune regulation, and is one of the most important signal transduction pathways mediated by cytokines. JAK/STAT is a relatively conserved signaling pathway in insects, which is the main immune pathway together with Toll signaling pathway and Imd signaling pathway to resist the invasion of pathogens. It plays a vital role in insect immunity, hormone regulation and other physiological regulation processes. In this review, we summarize the cytokine receptor superfamily, JAKs family, STATs family, JAK/STAT signaling pathway and its mechanism of negative feedback regulation. We analyze the important functions and the latest research progress of JAK/STAT signaling pathway in insect infected by parasites, viruses and fungi. Finally, we propose the remaining problems in the study of JAK/STAT signaling pathway, so as to provide direction and reference for further research in this field.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Citocinas
Idioma:
En
Revista:
Yi Chuan
Asunto de la revista:
GENETICA
Año:
2023
Tipo del documento:
Article
País de afiliación:
China