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Outcomes of Transfusion With Whole Blood, Component Therapy, or Both in Adult Civilian Trauma Patients: A Systematic Review and Meta-Analysis.
Ngatuvai, Micah; Zagales, Israel; Sauder, Matthew; Andrade, Ryan; Santos, Radleigh G; Bilski, Tracy; Kornblith, Lucy; Elkbuli, Adel.
Afiliación
  • Ngatuvai M; Dr Kiran.C. Patel College of Allopathic Medicine, NSU NOVA Southeastern University, Fort Lauderdale, Florida.
  • Zagales I; Universidad Iberoamericana (UNIBE) Escuela de Medicina, Santo Domingo, Dominican Republic.
  • Sauder M; Dr Kiran.C. Patel College of Allopathic Medicine, NSU NOVA Southeastern University, Fort Lauderdale, Florida.
  • Andrade R; A.T. Still University School of Osteopathic Medicine, Mesa, Arizona.
  • Santos RG; Department of Mathematics, NSU NOVA Southeastern University, Fort Lauderdale, Florida.
  • Bilski T; Division of Trauma and Surgical Critical Care, Department of Surgery, Orlando Regional Medical Center, Orlando, Florida; Department of Surgical Education, Orlando Regional Medical Center, Orlando, Florida.
  • Kornblith L; Division of Trauma and Surgical Critical Care, Department of Surgery, Zuckerberg San Francisco General Hospital & Trauma Center, San Francisco, California; Department of Surgery, University of San Francisco, San Francisco, California.
  • Elkbuli A; Division of Trauma and Surgical Critical Care, Department of Surgery, Orlando Regional Medical Center, Orlando, Florida; Department of Surgical Education, Orlando Regional Medical Center, Orlando, Florida. Electronic address: Adel.Elkbuli@orlandohealth.com.
J Surg Res ; 287: 193-201, 2023 07.
Article en En | MEDLINE | ID: mdl-36947979
INTRODUCTION: This systematic review and meta-analysis was conducted to compare outcomes, including transfusion volume, complications, intensive care unit length of stay, and mortality for adult civilian trauma patients transfused with whole blood (WB), components (COMP), or both (WB + COMP). METHODS: A systematic review and meta-analysis were conducted using studies that evaluated outcomes of transfusion of WB, COMP, or WB + COMP for adult civilian trauma patients. A search of PubMed, Embase, and Cochrane from database inception to March 3, 2022 was conducted. The search resulted in 18,400 initial articles with 16 studies remaining after the removal of duplicates and screening for inclusion and exclusion criteria. RESULTS: This study identified an increased risk of 24-h mortality with COMP versus WB + COMP (relative risk: 1.40 [1.10, 1.78]) and increased transfusion volumes of red blood cells with COMP versus WB at 6 and 24 h, respectively (-2.26 [-3.82, -0.70]; -1.94 [-3.22, -0.65] units). There were no differences in the calculated rates of infections or intensive care unit length of stay between WB and COMP, respectively (relative risks: 1.35 [0.53, 3.46]; -0.91 [-2.64, 0.83]). CONCLUSIONS: Transfusion with WB + COMP is associated with lower 24-h mortality versus COMP and transfusion with WB is associated with a lower volume of red blood cells transfused at both 6 and 24 h. Based on these findings, greater utilization of whole blood in civilian adult trauma resuscitation may lead to improved mortality and reduced transfusion requirements.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Heridas y Lesiones / Transfusión Sanguínea Tipo de estudio: Etiology_studies / Prognostic_studies / Systematic_reviews Límite: Adult / Humans Idioma: En Revista: J Surg Res Año: 2023 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Heridas y Lesiones / Transfusión Sanguínea Tipo de estudio: Etiology_studies / Prognostic_studies / Systematic_reviews Límite: Adult / Humans Idioma: En Revista: J Surg Res Año: 2023 Tipo del documento: Article