Host-mediated RNA editing in viruses.
Biol Direct
; 18(1): 12, 2023 03 28.
Article
en En
| MEDLINE
| ID: mdl-36978112
ABSTRACT
Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA editing, as a crucial co-/post-transcriptional modification inducing nucleotide alterations on both endogenous and exogenous RNA sequences, exerts significant influences on virus replication, protein synthesis, infectivity and toxicity. Hitherto, a number of host-mediated RNA editing sites have been identified in diverse viruses, yet lacking a full picture of RNA editing-associated mechanisms and effects in different classes of viruses. Here we synthesize the current knowledge of host-mediated RNA editing in a variety of viruses by considering two enzyme families, viz., ADARs and APOBECs, thereby presenting a landscape of diverse editing mechanisms and effects between viruses and hosts. In the ongoing pandemic, our study promises to provide potentially valuable insights for better understanding host-mediated RNA editing on ever-reported and newly-emerging viruses.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Virus
/
COVID-19
Límite:
Humans
Idioma:
En
Revista:
Biol Direct
Año:
2023
Tipo del documento:
Article
País de afiliación:
China