Epidemiology of hospitalisations due to chickenpox and quality of life lost in community and hospital settings: protocol for a prospective cohort study across two countries.
BMJ Open
; 13(3): e068611, 2023 03 29.
Article
en En
| MEDLINE
| ID: mdl-36990479
ABSTRACT
INTRODUCTION:
While still a ubiquitous disease of childhood, chickenpox has been effectively controlled in many countries through the use of vaccination. Previous health economic assessment of the use of these vaccines in the UK were based on limited quality of life data and only routinely collected epidemiological outcomes. METHODS ANDANALYSIS:
This two armed study will carry prospective surveillance of hospital admissions and recruit from community settings to measure the acute quality of life loss caused by paediatric chickenpox both in the UK and in Portugal. The quality of life effects on children and their primary and secondary caregivers will be assessed using the EuroQol EQ-5D with the Child Health Utility instrument (CHU-9) in addition for children. Results will be used to derive quality-adjusted life year loss estimates for cases of simple varicella and the secondary complications. ETHICS AND DISSEMINATION We have received National Health Service ethical approval (REC ref 18/ES/0040) for the inpatient arm, university ethical approval (University of Bristol ref 60721) for the community arm and 10 sites currently are recruiting in the UK and 14 in Portugal. Informed consent is obtained from the parent(s). Results will be disseminated in peer-reviewed publications. TRIAL REGISTRATION NUMBER ISRCTN15017985.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Varicela
Tipo de estudio:
Etiology_studies
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Observational_studies
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Risk_factors_studies
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Screening_studies
Límite:
Child
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Humans
Idioma:
En
Revista:
BMJ Open
Año:
2023
Tipo del documento:
Article
País de afiliación:
Reino Unido