Resveratrol protects against postmenopausal atherosclerosis progression through reducing PCSK9 expression via the regulation of the ER&#945;-mediated signaling pathway.

Jing, Yi; Hu, Tianhui; Yuan, Jun; Liu, Zhikun; Tao, Mingtao; Ou, Mingyu; Cheng, Xinru; Cheng, Wei; Yi, Yuanyuan; Xiong, Qingping

Resveratrol protects against postmenopausal atherosclerosis progression through reducing PCSK9 expression via the regulation of the ERα-mediated signaling pathway.

Jing, Yi; Hu, Tianhui; Yuan, Jun; Liu, Zhikun; Tao, Mingtao; Ou, Mingyu; Cheng, Xinru; Cheng, Wei; Yi, Yuanyuan; Xiong, Qingping.

Afiliación

Jing Y; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, China. Electronic address: jingyi@hyit.edu.cn.
Hu T; Traditional Chinese Medicine Department, Huai'an Maternal and Child Health-Care Center, Huai'an 223003, China.
Yuan J; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, China.
Liu Z; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, China.
Tao M; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, China.
Ou M; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, China.
Cheng X; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, China.
Cheng W; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, China.
Yi Y; The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Xiong Q; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, China. Electronic address: sqpsyy@hyit.edu.cn.

Biochem Pharmacol ; 211: 115541, 2023 05.

Article en En | MEDLINE | ID: mdl-37030661

Asunto(s)

Aterosclerosis; Proproteína Convertasa 9; Ratones; Animales; Proproteína Convertasa 9/genética; Proproteína Convertasa 9/metabolismo; Resveratrol/farmacología; Subtilisina/metabolismo; Receptor alfa de Estrógeno/genética; Receptor alfa de Estrógeno/metabolismo; Posmenopausia; Ratones Noqueados para ApoE; Proproteína Convertasas/metabolismo; Aterosclerosis/tratamiento farmacológico; Aterosclerosis/prevención & control; Aterosclerosis/metabolismo; Transducción de Señal; Receptores de LDL/genética; Receptores de LDL/metabolismo

Palabras clave

Atherosclerosis; Estradiol; Estrogen receptor α; Insulin; PCSK9; Resveratrol

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aterosclerosis / Proproteína Convertasa 9 Límite: Animals Idioma: En Revista: Biochem Pharmacol Año: 2023 Tipo del documento: Article

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