Impact of Divalent Metal Ions on Regulation of Trans-Cleavage Activity of CRISPR-Cas13a: A Combined Experimental and Computational Study.

Feng, Zhi-Yuan; Yun, Yang-Fang; Li, Xiang; Zhang, Jingjing

Feng, Zhi-Yuan; Yun, Yang-Fang; Li, Xiang; Zhang, Jingjing.

Afiliación

Feng ZY; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, 210023, China.
Yun YF; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, 210023, China.
Li X; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, 210023, China.
Zhang J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, 210023, China.

Chembiochem ; 24(10): e202300034, 2023 05 16.

Article en En | MEDLINE | ID: mdl-37040174

Asunto(s)

Manganeso; ARN; Calcio/metabolismo; Conformación Molecular; Magnesio; Sistemas CRISPR-Cas

Palabras clave

CRISPR; RNA detection; divalent metal Ions; molecular dynamics simulation; trans-cleavage activity

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ARN / Manganeso Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China

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