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Pediatric Extracranial Germ Cell Tumors: Review of Clinics and Perspectives in Application of Autologous Stem Cell Transplantation.
Lew, Chong-Zhi; Liu, Hsi-Che; Hou, Jen-Yin; Huang, Ting-Huan; Yeh, Ting-Chi.
Afiliación
  • Lew CZ; Division of Pediatric Hematology-Oncology, Department of Pediatrics, Mackay Children's Hospital, Mackay Medical College, Taipei 104, Taiwan.
  • Liu HC; Division of Pediatric Hematology-Oncology, Department of Pediatrics, Mackay Children's Hospital, Mackay Medical College, Taipei 104, Taiwan.
  • Hou JY; Division of Pediatric Hematology-Oncology, Department of Pediatrics, Mackay Children's Hospital, Mackay Medical College, Taipei 104, Taiwan.
  • Huang TH; Division of Pediatric Hematology-Oncology, Department of Pediatrics, Hsinchu Mackay Memorial Hospital, Hsinchu 300, Taiwan.
  • Yeh TC; Division of Pediatric Hematology-Oncology, Department of Pediatrics, Mackay Children's Hospital, Mackay Medical College, Taipei 104, Taiwan.
Cancers (Basel) ; 15(7)2023 Mar 27.
Article en En | MEDLINE | ID: mdl-37046659
Pediatric extracranial germ cell tumors (GCTs) are rare, accounting for approximately 3.5% of childhood cancers. Since the introduction of platinum-based chemotherapy, the survival rate of patients has improved to more than 80%. However, poor-risk subtypes of pediatric extracranial GCTs do not respond well to chemotherapy, leading to refractory or relapsed (R/R) diseases. For example, long-term survival rates of mediastinal GCTs or choriocarcinoma are less than 50%. According to reports in recent years for adult patients with R/R GCTs, the use of high-dose chemotherapy (HDCT) combined with autologous stem cell transplantation (ASCT) has clinical advantages; however, HDCT combined with ASCT has rarely been reported in pediatric GCTs. The R/R and poor-risk groups of pediatric GCTs could benefit from HDCT and ASCT.
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Taiwán

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Taiwán