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The presence of two light chain bands on immunofixation is associated with poor outcomes in newly diagnosed multiple myeloma patients.
Jerbi, Ameni; Turki, Omar; Hachicha, Hend; Kallel Sarbeji, Faten; Feki, Sawsan; Mejdoub, Sabrina; Kammoun, Khaoula; Ben Hmida, Mohamed; Elloumi, Moez; Masmoudi, Hatem.
Afiliación
  • Jerbi A; Immunology Department, Habib Bourguiba University Hospital, University of Sfax, 3000, Sfax, Tunisia. ameni.jerbi09@gmail.com.
  • Turki O; Immunology Department, Habib Bourguiba University Hospital, University of Sfax, 3000, Sfax, Tunisia.
  • Hachicha H; Immunology Department, Habib Bourguiba University Hospital, University of Sfax, 3000, Sfax, Tunisia.
  • Kallel Sarbeji F; Hematology Department, Hedi Chaker University Hospital, University of Sfax, 3000, Sfax, Tunisia.
  • Feki S; Immunology Department, Habib Bourguiba University Hospital, University of Sfax, 3000, Sfax, Tunisia.
  • Mejdoub S; Immunology Department, Habib Bourguiba University Hospital, University of Sfax, 3000, Sfax, Tunisia.
  • Kammoun K; Nephrology Department, Hedi Chaker University Hospital, University of Sfax, 3000, Sfax, Tunisia.
  • Ben Hmida M; Nephrology Department, Hedi Chaker University Hospital, University of Sfax, 3000, Sfax, Tunisia.
  • Elloumi M; Hematology Department, Hedi Chaker University Hospital, University of Sfax, 3000, Sfax, Tunisia.
  • Masmoudi H; Immunology Department, Habib Bourguiba University Hospital, University of Sfax, 3000, Sfax, Tunisia.
Ann Hematol ; 102(6): 1459-1466, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37060464
We aimed to describe the clinical and biological characteristics and the prognosis of patients presenting with an additional light chain (LC) band along with a complete monoclonal protein on immunofixation (IF).An 8-year descriptive study was conducted to assess all cases with confirmed monoclonal gammopathies (MG). We studied those with an entire M-protein with 2 bands of LC of the same isotype based on the results of IF. Data were collected from patients' files.Among 548 cases of MG, we found 32 cases (5.8%) with an additional LC band. We included 28 patients (5%) with a confirmed diagnosis of multiple myeloma (MM). The m/f ratio was 2.5 with a median age of 63 years [32-80 years]. All MM patients had anemia, 16 (57%) had renal failure, 14 (50%) had lytic lesions, 9 (32%) received hemodialysis, and 7 (25%) had hypercalcemia. The free-kappa-lambda ratio was abnormal in all cases: median = 0.07 [0.002-58.57]. The mean overall survival (OS) was 22 months ± 38.76.Fifteen MM patients (48%) received chemotherapy, and 7 (22%) autologous stem cell transplants (SCT). Patients who received SCT had an OS higher than those who received other treatments (p = 0.038). OS was low in patients with high ß2microglobulin levels (rho = -0.791; p = 0.001), and abnormally low free-kappa-lambda ratio (rho = -0.852;p = 0.04).The presence of an additional LC band with a complete monoclonal protein seems to identify newly diagnosed MM patients with poor outcomes and frequent renal impairment.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Paraproteinemias / Mieloma Múltiple Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Middle aged Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Túnez

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Paraproteinemias / Mieloma Múltiple Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Middle aged Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Túnez