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Lithographically patterned micro-nozzles for controlling fluid flow profiles for drug delivery and in vitro imaging applications.
Head, Tristen; Tokranova, Natalya; Cady, Nathaniel C.
Afiliación
  • Head T; College of Nanoscale Science & Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
  • Tokranova N; College of Nanoscale Science & Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
  • Cady NC; College of Nanoscale Science & Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
MRS Commun ; 11(5): 584-589, 2021 Oct.
Article en En | MEDLINE | ID: mdl-37063609
Precisely controlling delivery of drugs and other reagents is important for intravital microscopy studies. In this work, photolithographic integration of micro-nozzles onto a microfluidic platform was performed to tune the fluid flow profile and depth of penetration into biological tissue mimics. Performance characteristics were measured by correlating the flow rate through the device to the applied pressure and/or delivery of dyes into solution and agarose gel-based phantom tissue. From these results, the implementation of micro-nozzles was demonstrated to significantly improve the lateral dispersion of delivered fluid and increase the depth of penetration into phantom tissue.

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: MRS Commun Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: MRS Commun Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos