Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4.

Vaas, Sebastian; Zimmermann, Markus O; Klett, Theresa; Boeckler, Frank M

Vaas, Sebastian; Zimmermann, Markus O; Klett, Theresa; Boeckler, Frank M.

Afiliación

Vaas S; Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, Laboratory for Molecular Design and Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany.
Zimmermann MO; Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, Laboratory for Molecular Design and Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany.
Klett T; Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, Laboratory for Molecular Design and Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany.
Boeckler FM; Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, Laboratory for Molecular Design and Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Tübingen, 72076, Germany.

Drug Des Devel Ther ; 17: 1247-1274, 2023.

Article en En | MEDLINE | ID: mdl-37128274

Asunto(s)

Aminoácidos; Proteína p53 Supresora de Tumor; Humanos; Péptidos/química; Halógenos/química; Proteínas Proto-Oncogénicas c-mdm2/química; Proteínas Proto-Oncogénicas; Proteínas de Ciclo Celular

Palabras clave

MdmX; fluorescence polarization assay; halogen bonding; oncological target; solid-phase peptide synthesis; unnatural amino acids

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Aminoácidos Límite: Humans Idioma: En Revista: Drug Des Devel Ther Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2023 Tipo del documento: Article País de afiliación: Alemania

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