Insights into the Roles of B Cells in Patients with Sepsis.
J Immunol Res
; 2023: 7408967, 2023.
Article
en En
| MEDLINE
| ID: mdl-37128298
ABSTRACT
Sepsis is a life-threatening yet common disease, still posing high mortality worldwide. Sepsis-related deaths primarily occur during immunosuppression; the disease can hamper the numbers and function of B cells, which mediate innate and adaptive immune responses to maintain immune homeostasis. Dysfunction of B cells, along with aggravated immunosuppression, are closely related to poor prognosis. However, B cells in patients with sepsis have garnered little attention. This article focuses on the significance of B-cell subsets, including regulatory B cells, in sepsis and how the counts and function of circulating B cells are affected in patients with sepsis. Finally, potential B-cell-related immunotherapies for sepsis are explored.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sepsis
/
Linfocitos B Reguladores
Límite:
Humans
Idioma:
En
Revista:
J Immunol Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
China