CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats.

Jin, Long; Shen, Nan; Wen, Xinyu; Wang, Weidong; Lim, Sun Woo; Yang, Chul Woo

Jin, Long; Shen, Nan; Wen, Xinyu; Wang, Weidong; Lim, Sun Woo; Yang, Chul Woo.

Afiliación

Jin L; Department of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Shen N; Department of Nephrology, Air Force Medical Center,Air Force Medical University, Beijing, China.
Wen X; Department of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Wang W; Department of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Lim SW; Department of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Yang CW; Transplant Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Korean J Intern Med ; 38(3): 393-405, 2023 05.

Article en En | MEDLINE | ID: mdl-37157174

Asunto(s)

Insuficiencia Renal; Tacrolimus; Ratas; Humanos; Animales; Tacrolimus/farmacología; Abatacept/farmacología; Abatacept/metabolismo; Factor I del Crecimiento Similar a la Insulina/metabolismo; Factor I del Crecimiento Similar a la Insulina/farmacología; Proteínas Proto-Oncogénicas c-akt; Especies Reactivas de Oxígeno; Ratas Sprague-Dawley; Transducción de Señal; Estrés Oxidativo; Apoptosis; Proteínas Reguladoras de la Apoptosis/metabolismo; Proteína Forkhead Box O3/metabolismo; Antígeno CTLA-4

Palabras clave

AKT/FOXO3 signaling pathway; CTLA4-Ig; Renal injury; Tacrolimus

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tacrolimus / Insuficiencia Renal Límite: Animals / Humans Idioma: En Revista: Korean J Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2023 Tipo del documento: Article País de afiliación: China

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