Human T cells efficiently control RSV infection.
JCI Insight
; 8(11)2023 06 08.
Article
en En
| MEDLINE
| ID: mdl-37159271
Respiratory syncytial virus (RSV) infection causes significant morbidity and mortality in infants, immunocompromised individuals, and older individuals. There is an urgent need for effective antivirals and vaccines for high-risk individuals. We used 2 complementary in vivo models to analyze RSV-associated human lung pathology and human immune correlates of protection. RSV infection resulted in widespread human lung epithelial damage, a proinflammatory innate immune response, and elicited a natural adaptive human immune response that conferred protective immunity. We demonstrated a key role for human T cells in controlling RSV infection. Specifically, primed human CD8+ T cells or CD4+ T cells effectively and independently control RSV replication in human lung tissue in the absence of an RSV-specific antibody response. These preclinical data support the development of RSV vaccines, which also elicit effective T cell responses to improve RSV vaccine efficacy.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Infecciones por Virus Sincitial Respiratorio
Límite:
Humans
/
Infant
Idioma:
En
Revista:
JCI Insight
Año:
2023
Tipo del documento:
Article