Lipoprotein(a) As a Risk Factor in a Cohort of Hospitalised Cardiovascular Patients: A Retrospective Clinical Routine Data Analysis.
J Clin Med
; 12(9)2023 Apr 29.
Article
en En
| MEDLINE
| ID: mdl-37176660
ABSTRACT
INTRODUCTION:
Lipoprotein(a) (Lp(a)) is a well-recognised risk factor for ischemic heart disease (IHD) and calcific aortic valve stenosis (AVS).METHODS:
A retrospective observational study of Lp(a) levels (mg/dL) in patients hospitalised for cardiovascular diseases (CVD) in our clinical routine was performed. The Lp(a)-associated risk of hospitalisation for IHD, AVS, and concomitant IHD/AVS versus other non-ischemic CVDs (oCVD group) was assessed by means of logistic regression.RESULTS:
In total of 11,767 adult patients, the association with Lp(a) was strongest in the IHD/AVS group (eß = 1.010, p < 0.001), followed by the IHD (eß = 1.008, p < 0.001) and AVS group (eß = 1.004, p < 0.001). With increasing Lp(a) levels, the risk of IHD hospitalisation was higher compared with oCVD in women across all ages and in men aged ≤75 years. The risk of AVS hospitalisation was higher only in women aged ≤75 years (eß = 1.010 in age < 60 years, eß = 1.005 in age 60-75 years, p < 0.05).CONCLUSIONS:
The Lp(a)-associated risk was highest for concomitant IHD/AVS hospitalisations. The differential impact of sex and age was most pronounced in the AVS group with an increased risk only in women aged ≤75 years.
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Bases de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Clin Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Eslovenia