A phase 1 study to investigate the absorption, distribution, metabolism and excretion of brepocitinib in healthy males using a <sup>14</sup> C-microdose approach.

Qiu, Ruolun; Sharma, Raman; Wei, Hua; Kirkovsky, Leonid; Zhou, Yifan; Martin, David D A; Banfield, Christopher; Dowty, Martin E

A phase 1 study to investigate the absorption, distribution, metabolism and excretion of brepocitinib in healthy males using a ¹⁴ C-microdose approach.

Qiu, Ruolun; Sharma, Raman; Wei, Hua; Kirkovsky, Leonid; Zhou, Yifan; Martin, David D A; Banfield, Christopher; Dowty, Martin E.

Afiliación

Qiu R; Pfizer Inc, Cambridge, Massachusetts, USA.
Sharma R; Pfizer Inc, Groton, Connecticut, USA.
Wei H; Pfizer Inc, Shanghai, China.
Kirkovsky L; Pfizer Inc, La Jolla, California, USA.
Zhou Y; Pfizer Inc, Collegeville, Pennsylvania, USA.
Martin DDA; Pfizer Inc, Cambridge, Massachusetts, USA.
Banfield C; Pfizer Inc, Cambridge, Massachusetts, USA.
Dowty ME; Pfizer Inc, Cambridge, Massachusetts, USA.

Br J Clin Pharmacol ; 89(10): 3056-3066, 2023 10.

Article en En | MEDLINE | ID: mdl-37183779

Asunto(s)

Eliminación Renal; Humanos; Masculino; Heces; Disponibilidad Biológica; Administración Intravenosa; Administración Oral

Palabras clave

14C-microdose; absorption; brepocitinib; distribution; excretion; mass balance; metabolism

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Eliminación Renal Límite: Humans / Male Idioma: En Revista: Br J Clin Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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