Iron deficiency and its epigenetic effects on iron homeostasis.
J Trace Elem Med Biol
; 78: 127203, 2023 Jul.
Article
en En
| MEDLINE
| ID: mdl-37201368
ABSTRACT
Iron deficiency is a common micronutrient deficiency associated with metabolic changes in the levels of iron regulatory proteins, hepcidin and ferroportin. Studies have associated dysregulation of iron homeostasis to other secondary and life-threatening diseases including anaemia, neurodegeneration and metabolic diseases. Iron deficiency plays a critical role in epigenetic regulation by affecting the Fe2+/α-ketoglutarate-dependent demethylating enzymes, Ten Eleven Translocase 1-3 (TET 1-3) and Jumonji-C (JmjC) histone demethylase, which are involved in epigenetic erasure of the methylation marks on both DNA and histone tails, respectively. In this review, studies involving epigenetic effects of iron deficiency associated with dysregulation of TET 1-3 and JmjC histone demethylase enzyme activities on hepcidin/ferroportin axis are discussed.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Hepcidinas
/
Deficiencias de Hierro
Límite:
Humans
Idioma:
En
Revista:
J Trace Elem Med Biol
Asunto de la revista:
METABOLISMO
/
SAUDE AMBIENTAL
Año:
2023
Tipo del documento:
Article