Oral Mucosa Models to Evaluate Drug Permeability.
Pharmaceutics
; 15(5)2023 May 22.
Article
en En
| MEDLINE
| ID: mdl-37242801
ABSTRACT
Due to its numerous advantages, such as excellent drug accessibility, rapid absorption, and bypass of first-pass metabolism, the route of drug administration that involves crossing the oral mucosa is highly favored. As a result, there is significant interest in investigating the permeability of drugs through this region. The purpose of this review is to describe the various ex vivo and in vitro models used to study the permeability of conveyed and non-conveyed drugs through the oral mucosa, with a focus on the most effective models. Currently, there is a growing need for standardized models of this mucosa that can be used for developing new drug delivery systems. Oral Mucosa Equivalents (OMEs) may provide a promising future perspective as they are capable of overcoming limitations present in many existing models.
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Bases de datos:
MEDLINE
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En
Revista:
Pharmaceutics
Año:
2023
Tipo del documento:
Article
País de afiliación:
Italia