Multi-input Drug-Controlled Switches of Mammalian Gene Expression Based on Engineered Nuclear Hormone Receptors.

Kretschmer, Simon; Perry, Nicholas; Zhang, Yang; Kortemme, Tanja

Kretschmer, Simon; Perry, Nicholas; Zhang, Yang; Kortemme, Tanja.

Afiliación

Kretschmer S; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, United States.
Perry N; California Quantitative Biosciences Institute (QBI) at UCSF, San Francisco, California 94158, United States.
Zhang Y; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, United States.
Kortemme T; California Quantitative Biosciences Institute (QBI) at UCSF, San Francisco, California 94158, United States.

ACS Synth Biol ; 12(7): 1924-1934, 2023 07 21.

Article en En | MEDLINE | ID: mdl-37315218

Asunto(s)

Expresión Génica; Receptores Citoplasmáticos y Nucleares/agonistas; Receptores Citoplasmáticos y Nucleares/genética; Receptores Citoplasmáticos y Nucleares/metabolismo; Control de Medicamentos y Narcóticos; Humanos; Genes Reporteros; Ligandos; Sitios de Unión

Palabras clave

cell engineering; modularity; multi-input switches; nuclear hormone receptors; protein engineering; synthetic biology

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Expresión Génica Límite: Humans Idioma: En Revista: ACS Synth Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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