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Comparative impact of grade on mortality across salivary cancers: A novel, unifying staging system.
Ho, Allen S; Luu, Michael; Balzer, Bonnie L; Aro, Katri; Jang, Julie K; Mita, Alain C; Scher, Kevin S; Mallen-St Clair, Jon; Vasquez, Missael; Bastien, Amanda J; Epstein, Joel B; Lin, De-Chen; Chen, Michelle M; Zumsteg, Zachary S.
Afiliación
  • Ho AS; Samuel Oschin Comprehensive Cancer Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Luu M; Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Balzer BL; Samuel Oschin Comprehensive Cancer Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Aro K; Biostatistics and Bioinformatics Research Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Jang JK; Samuel Oschin Comprehensive Cancer Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Mita AC; Department of Pathology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Scher KS; Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Mallen-St Clair J; Samuel Oschin Comprehensive Cancer Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Vasquez M; Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Bastien AJ; Samuel Oschin Comprehensive Cancer Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Epstein JB; Division of Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Lin DC; Samuel Oschin Comprehensive Cancer Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Chen MM; Division of Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Zumsteg ZS; Samuel Oschin Comprehensive Cancer Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Head Neck ; 45(8): 2028-2039, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37345665
ABSTRACT

BACKGROUND:

The comparative impact of histologic variants and grade has not been well described.

METHODS:

Salivary cancer histologies were profiled using hospital and population-based cancer registries. Multivariable models were employed to assess relationships between histology, grade, and survival.

RESULTS:

On univariate analysis, histologic variants exhibited a wide spectrum of mortality risk (5-year overall survival (OS) 86% (acinic cell carcinoma), 78% (mucoepidermoid carcinoma), 72% (adenoid cystic carcinoma), 64% (carcinoma ex-pleomorphic adenoma), 52% (adenocarcinoma NOS), and 47% (salivary duct carcinoma) (p < 0.001). However, on multivariable analysis these differences largely vanished. Worsening grade corresponded with deteriorating survival (5-year OS 89% [low-grade], 81% [intermediate-grade], 45% [high-grade]; p < 0.001), which was upheld on multivariable analysis and propensity score matching. Recursive partitioning analysis generated TNM + G schema (c-index 0.75) superior to the existing system (c-index 0.73).

CONCLUSION:

Grade represents a primary determinant of salivary cancer prognosis. Integrating grade into stage strengthens current staging systems.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Carcinoma Mucoepidermoide / Carcinoma de Células Acinares / Carcinoma Adenoide Quístico / Adenoma Pleomórfico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Finlandia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Carcinoma Mucoepidermoide / Carcinoma de Células Acinares / Carcinoma Adenoide Quístico / Adenoma Pleomórfico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Finlandia